Relationship between Serum Lipoprotein Levels and Insulin Resistance in Non-obese Women with Polycystic Ovary Syndrome

Background: To investigate the association between serum lipoprotein levels and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods: Twenty-five PCOS patients and twentyfive age-matched controls were enrolled in the study. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), fasting glucose (FBG), fasting insulin (FINS), serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) levels were estimated. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate the insulin resistance. Results: The mean arterial pressure, TAG, LDL-C, serum insulin, HOMA-IR and serum LH levels were significantly higher in PCOS patients as compared to healthy controls, whereas no significant differences in BMI, fasting glucose, serum cholesterol, HDL-C and FSH levels were observed between PCOS patients and controls. Conclusion: Serum lipoprotein ratio significantly correlates with insulin resistance and can be used as the marker of insulin resistance in PCOS patients.